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KMID : 0364019940270090723
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Korean Journal of Thoracic and Cardiovascular Surgery
1994 Volume.27 No. 9 p.723 ~ p.731
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The Experimental Study for Islated Rabbit Lung Preservation
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Abstract
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We have modified the isolated perfused working rabbit lung model(IPWL) by perfusing the isolated lung with a hollow fiber membrane deoxygenator.
For assessment the stored lung was ventilated with FIO2 0.4 and perfused with 37℃ deoxgenated circulating blood at a rate 5ml/kg/min for several hours lung failure.
We chose to compare our developing solution which contained low potassium and pentastarch, with the modified Euro-Collins solution.
Experiments were devided into four groups(n=6) based on the type of flushing preservation solution and preservation time.
The flushed lungs were then preserved into same solution at 8~10℃ with 100% O2 inflated condition for 1 or 20 hours.
These following results were obtained.
The IPWL model requires only one animal per experiment and allows for the continuous assessment of aerodynamic performance. This should therefore be used as screening test in lung preservation.
One hour preservation groups, there were no significant difference in recovery rates of PaO2, PAP and Paw. Survival time in the one hour preservation groups were very significant long in the Group II (LPPS, p<0.01).
Twenty hours preservation groups, there were no significant difference in the recovery rates of PAP and Paw between Group III(m-ECS) and Group IV (NS), but PaO2 was significantly worse at onset of reperfusion in Group III when companed with Group
IV(p<0.05). Andalso survival time in the 20 hours preservation groups were significant long in the Group IV(p<0.05). (Korean J Thoracic Cardiovas Surg 1994; 27:723-31)
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